SEC Form 4 · Updated Daily

ISIS

Insider and institutional ownership derived from SEC Form 4 filings. Click any owner to see their holdings across every company they’ve filed on, and how their position has changed over time.

FinancialsOwnership

Current Reporting Owners

OwnerRoleShares OwnedAs OfLast Activity
HOUGEN ELIZABETH LOfficer307,8802026-03-16M
Monia Brett PDirector · Officer242,7602026-08-31J
BERTHELSEN SPENCER RDirector161,2332026-07-15M
LOSCALZO JOSEPHDirector113,6192026-05-04M
Schneider EugeneOfficer103,1142026-06-26M
Birchler BrianOfficer102,8832026-08-31J
Geary Richard SOfficer77,9572025-11-06M
BENNETT C FRANKOfficer60,1282026-08-31J
MUTO FREDERICK TDirector59,5972022-07-15M
O'NEIL PATRICK R.Officer59,2052026-08-31J
PARSHALL B LYNNEDirector51,8782026-04-15S
HERMAN JOAN EDirector51,3062026-07-15M
WENDER JOSEPH HDirector43,4642025-12-01S
Cadoret-Manier OnaizaOfficer35,7882024-02-02S
Jenne KyleOfficer28,6152026-04-15M
Hayden Michael RDirector24,0002026-07-31P
KLEIN JOSEPH IIIDirector22,5322026-07-01M
Kordasiewicz Holly B.Officer22,0962026-07-07S
Treble Michael JOfficer20,0002008-08-11M
Castleman BreauxDirector19,1832020-07-06M
Devers Shannon L.Officer19,1682026-10-15M
Reikes Peter NDirector14,2222021-10-15M
Diaz Allene M.Director13,9222026-07-07M
Wedel Mark KOfficer11,8032007-07-06M
Boyce SarahReporting Owner11,1272018-01-15M
Baroldi JosephOfficer10,3042026-06-26M
ECKER DAVID JOfficer10,0002008-09-02M
YANG MICHAEL J.Director7,9402026-01-15M
LEVIN ARTHUR AOfficer7,6742007-04-25M
BROWN RICHARD KOfficer5,1182006-03-08M
REED JOHN COfficer5,1002012-09-04M
McDevitt DamienOfficer3,7982019-07-15M
CROOKE STANLEY TDirector · Officer2,0212021-01-26S
Swayze EricOfficer4432026-10-15M
JONAS JEFFREY MOfficer02007-02-01—
XANTHOPOULOS KLEANTHIS GOfficer02007-12-03—

Recent Filings

DateOwnerActivitySharesPriceOwned After
2026-10-16Swayze EricOpen-market sale53$43.54390
2026-10-16Devers Shannon L.Open-market sale1,357$43.5417,811
2026-10-15Swayze EricOption exercise (derivative)125$0.00486
2026-10-15Swayze EricOption exercise125$0.00443
2026-10-15Devers Shannon L.Option exercise (derivative)2,820$0.0049,884
2026-10-15Devers Shannon L.Option exercise2,820$0.0019,168
2026-08-31Birchler BrianJ58$51.31102,883
2026-08-31Monia Brett PJ98$51.31242,760
2026-08-31O'NEIL PATRICK R.J63$51.3159,205
2026-08-31BENNETT C FRANKJ110$51.3160,128
2026-07-31Hayden Michael ROpen-market buy5,000$51.6024,000
2026-07-30Hayden Michael ROpen-market buy15,000$53.3819,000
2026-07-15BERTHELSEN SPENCER ROption exercise (derivative)5,220$0.002,301
2026-07-15BERTHELSEN SPENCER ROption exercise5,220$0.00161,233
2026-07-15HERMAN JOAN EOption exercise (derivative)5,220$0.002,301
2026-07-15HERMAN JOAN EOption exercise5,220$0.0051,306
2026-07-15HANTSON LUDWIGGrant / award (derivative)3,399$0.003,399
2026-07-15Reikes Peter NGrant / award (derivative)3,399$0.003,399
2026-07-07Kordasiewicz Holly B.Open-market sale362$84.3022,096
2026-07-07Diaz Allene M.Option exercise (derivative)10,111$0.000
2026-07-07Diaz Allene M.Open-market sale10,111$85.423,811
2026-07-07Diaz Allene M.Option exercise10,111$47.1113,922
2026-07-07BENNETT C FRANKJ (derivative)15,000$0.0012,109
2026-07-07BENNETT C FRANKOpen-market sale15,000$85.460
2026-07-07BENNETT C FRANKJ15,000$0.0015,000
2026-07-07BENNETT C FRANKOpen-market sale5,536$83.5875,018
2026-07-01BERTHELSEN SPENCER RGrant / award (derivative)2,301$0.007,521
2026-07-01BERTHELSEN SPENCER RGrant / award (derivative)5,369$0.005,369
2026-07-01Diaz Allene M.Grant / award (derivative)2,301$0.007,521
2026-07-01Diaz Allene M.Grant / award (derivative)5,369$0.005,369
2026-07-01Hayden Michael RGrant / award (derivative)2,301$0.0012,198
2026-07-01Hayden Michael RGrant / award (derivative)5,369$0.005,369
2026-07-01KLEIN JOSEPH IIIGrant / award (derivative)2,301$0.0016,277
2026-07-01KLEIN JOSEPH IIIGrant / award (derivative)5,369$0.005,369
2026-07-01KLEIN JOSEPH IIIOption exercise (derivative)11,518$0.000
2026-07-01KLEIN JOSEPH IIIOpen-market sale11,419$79.0411,014
2026-07-01KLEIN JOSEPH IIIOpen-market sale99$79.4522,433
2026-07-01KLEIN JOSEPH IIIOption exercise11,518$39.9422,532
2026-07-01HERMAN JOAN EGrant / award (derivative)2,301$0.007,521
2026-07-01HERMAN JOAN EGrant / award (derivative)5,369$0.005,369

Source: SEC EDGAR Form 4 filings. For informational purposes only — not investment advice.